CX3CR1 Is Expressed by Human B Lymphocytes and Meditates CX3CL1 Driven Chemotaxis of Tonsil Centrocytes

@article{Corcione2009CX3CR1IE,
  title={CX3CR1 Is Expressed by Human B Lymphocytes and Meditates CX3CL1 Driven Chemotaxis of Tonsil Centrocytes},
  author={Anna Corcione and Elisa Ferretti and Maria Bianca Bertolotto and Franco Fais and Lizzia Raffaghello and Andrea Gregorio and Claudya Tenca and Luciano Ottonello and Claudio Gambini and Glaucia C Furtado and S{\'e}rgio Lira and Vito Pistoia},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={602 - 607}
}
  • Anna Corcione, Elisa Ferretti, +9 authors Vito Pistoia
  • Published in PloS one 2009
  • Medicine, Biology
  • PLoS ONE
  • BACKGROUND Fractalkine/CX(3)CL1, a surface chemokine, binds to CX(3)CR1 expressed by different lymphocyte subsets. Since CX(3)CL1 has been detected in the germinal centres of secondary lymphoid tissue, in this study we have investigated CX(3)CR1 expression and function in human naïve, germinal centre and memory B cells isolated from tonsil or peripheral blood. METHODOLOGY/PRINCIPAL FINDINGS We demonstrate unambiguously that highly purified human B cells from tonsil and peripheral blood… CONTINUE READING

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