CX3CL1 protects neurons against excitotoxicity enhancing GLT-1 activity on astrocytes.


In this paper we show for the first time that: i) astrocytes are required for the neuroprotective activity of CX3CL1 against excitotoxicity; ii) inhibition of the glutamate transporter 1 (GLT-1) prejudices CX3CL1-mediated neuroprotection; iii) CX3CL1 increases GLT-1 activity on astrocytes. The modulation of GLT-1 activity induced by CX3CL1 on astrocytes… (More)
DOI: 10.1016/j.jneuroim.2013.07.020