CVT-124, a novel adenosine A1 receptor antagonist with unique diuretic activity.

@article{Gellai1998CVT124AN,
  title={CVT-124, a novel adenosine A1 receptor antagonist with unique diuretic activity.},
  author={Miklos Gellai and George F. Schreiner and Robert R. Ruffolo and Thomas L. Fletcher and R. S. Dewolf and David P. Brooks},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 3},
  pages={
          1191-6
        }
}
Administration of the selective adenosine A1 receptor antagonist, CVT-124, to conscious chronically instrumented rats resulted in significant increases in urine flow rate and sodium excretion without affecting potassium excretion or renal hemodynamics. Its maximum effect was twice that of hydrochlorothiazide which was associated with a significant kaliuresis. The diuretic effect of CVT-124 was less than that observed with furosemide; however, furosemide administration was associated with a… CONTINUE READING

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