CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury.

@article{Rebello1997CVS1123AD,
  title={CVS-1123, a direct thrombin inhibitor, prevents occlusive arterial and venous thrombosis in a canine model of vascular injury.},
  author={S. Rebello and B. Miller and G. Basler and B. Lucchesi},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={29 2},
  pages={
          240-9
        }
}
  • S. Rebello, B. Miller, +1 author B. Lucchesi
  • Published 1997
  • Medicine
  • Journal of cardiovascular pharmacology
  • CVS-1123, low-molecular-weight, direct thrombin inhibitor was studied in an anesthetized canine model of arterial and venous thrombosis to determine whether thrombin inhibition could reduce the incidence of occlusive thrombosis in response to vessel-wall injury. The left carotid artery (LCA) and right jugular vein (RJV) were instrumented with a flow probe, intraluminal electrode, and critical stenosis. Either saline (n = 9), or CVS-1123 (n = 12) was administered in a loading dose of 2 mg/kg i.v… CONTINUE READING
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