CVID patients with autoimmunity have elevated T cell expression of granzyme B and HLA-DR and reduced levels of Treg cells.

@article{Carter2013CVIDPW,
  title={CVID patients with autoimmunity have elevated T cell expression of granzyme B and HLA-DR and reduced levels of Treg cells.},
  author={Clive R. D. Carter and G. Aravind and Natuley L Smalle and June Y Cole and Sinisa Savic and Philip Matchett Wood},
  journal={Journal of clinical pathology},
  year={2013},
  volume={66 2},
  pages={146-50}
}
AIMS Common variable immunodeficiency (CVID) is a primary antibody immunodeficiency with approximately 20% of patients reporting additional autoimmune symptoms. The primary aim of this study was to compare the levels of activated and regulatory T cells (Treg cells) in CVID patients in an attempt to clarify their possible interactions leading to the generation of autoimmunity. METHODS Immunophenotyping of T cells was performed by flow cytometry using a whole blood approach. Surface expression… CONTINUE READING
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