CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC.

@article{Congrains2012CVDassociatedNR,
  title={CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC.},
  author={Ada Congrains and Kei Kamide and Tomohiro Katsuya and O. Yasuda and Ryousuke Oguro and Koichi Yamamoto and Mitsuru Ohishi and Hiromi Rakugi},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={419 4},
  pages={612-6}
}
ANRIL is a newly discovered non-coding RNA lying on the strongest genetic susceptibility locus for cardiovascular disease (CVD) in the chromosome 9p21 region. Genome-wide association studies have been linking polymorphisms in this locus with CVD and several other major diseases such as diabetes and cancer. The role of this non-coding RNA in atherosclerosis progression is still poorly understood. In this study, we investigated the implication of ANRIL in the modulation of gene sets directly… CONTINUE READING