CUL4B promotes proliferation and inhibits apoptosis of human osteosarcoma cells.

Abstract

Cullin 4B (CUL4B) is a component of the Cullin4B-Ring E3 ligase complex (CRL4B) that functions in proteolysis and is implicated in tumorigenesis. Here, we report that CUL4B is associated with tumorigenesis by promoting proliferation and inhibiting apoptosis of human osteosarcoma cells. We performed RNA interference (RNAi) with a lentiviral vector system to… (More)
DOI: 10.3892/or.2014.3465

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