CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.

@article{Zhang2003CUL4ASU,
  title={CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.},
  author={Yue Zhang and Giovanni Morrone and Jianxuan Zhang and Xiaoai Chen and Xiaoling Lu and Liang Ma and Malcolm A. S. Moore and Pengbo Zhou},
  journal={The EMBO journal},
  year={2003},
  volume={22 22},
  pages={6057-67}
}
The HOXA9 homeodomain protein is a key regulator of hematopoiesis and embryonic development. HOXA9 is expressed in primitive hematopoietic cells, and its prompt downregulation is associated with myelocytic maturation. Although transcriptional inactivation of HOXA9 during hematopoietic differentiation has been established, little is known about the biochemical mechanisms underlying the subsequent removal of HOXA9 protein. Here we report that the CUL-4A ubiquitylation machinery controls the… CONTINUE READING