CUBN as a Novel Locus for End-Stage Renal Disease: Insights from Renal Transplantation

@inproceedings{Reznichenko2012CUBNAA,
  title={CUBN as a Novel Locus for End-Stage Renal Disease: Insights from Renal Transplantation},
  author={Anna I. Reznichenko and Harold Snieder and Jacob van den Born and Martin H de Borst and Jeffrey Damman and Marcory Crf van Dijk and Harry van Goor and Bouke G. Hepkema and J. L. Hillebrands and Henri G. D. Leuvenink and Jan Niesing and Stephan J. L. Bakker and Marc A. J. Seelen and Gerjan J. Navis},
  booktitle={PloS one},
  year={2012}
}
Chronic kidney disease (CKD) is a complex disorder. As genome-wide association studies identified cubilin gene CUBN as a locus for albuminuria, and urinary protein loss is a risk factor for progressive CKD, we tested the hypothesis that common genetic variants in CUBN are associated with end-stage renal disease (ESRD) and proteinuria. First, a total of 1142 patients with ESRD, admitted for renal transplantation, and 1186 donors were genotyped for SNPs rs7918972 and rs1801239 (case-control study… CONTINUE READING

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