CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.

@article{Pearson1993CTXGE,
  title={CTX genetic element encodes a site-specific recombination system and an intestinal colonization factor.},
  author={Gregory D. N. Pearson and Angela Woods and Su L. Chiang and John J Mekalanos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 8},
  pages={
          3750-4
        }
}
  • Gregory D. N. Pearson, Angela Woods, +1 author John J Mekalanos
  • Published in
    Proceedings of the National…
    1993
  • Biology, Medicine
  • In Vibrio cholerae, the genes encoding cholera toxin (ctxAB) are located on a segment of DNA (termed the "core" region) that is flanked by two or more copies of a repeated sequence called RS1. Together these DNA units comprise the CTX genetic element. Evidence presented here suggests that RS1 sequences encode a site-specific recombination system, which allows integration of a suicide plasmid carrying RS1 into an 18-base-pair sequence (attRS1) located on the chromosome of nontoxigenic V… CONTINUE READING

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