CTX-M-type beta-lactamases: an emerging group of extended-spectrum enzymes.

  title={CTX-M-type beta-lactamases: an emerging group of extended-spectrum enzymes.},
  author={Leonidas S. Tzouvelekis and Eva Tzelepi and Panayotis T. Tassios and Nicholas John Legakis},
  journal={International journal of antimicrobial agents},
  volume={14 2},
CTX-M-type beta-lactamases constitute a novel group of class A beta-lactamases with extended-spectrum properties. They are encoded by transferable plasmids and found in various enterobacteria, mostly Salmonella typhimurium, Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. CTX-M enzymes share extensive sequence similarity with the chromosomal beta-lactamases of Klebsiella oxytoca. They efficiently hydrolyze many newer broad-spectrum oximino-beta-lactams including cefotaxime… CONTINUE READING

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