CTX-M Enzymes: Origin and Diffusion

  title={CTX-M Enzymes: Origin and Diffusion},
  author={Rafael Cant{\'o}n and Jos{\'e} Mar{\'i}a Gonz{\'a}lez-Alba and Juan Carlos Gal{\'a}n},
  booktitle={Front. Microbio.},
CTX-M β-lactamases are considered a paradigm in the evolution of a resistance mechanism. Incorporation of different chromosomal bla(CTX-M) related genes from different species of Kluyvera has derived in different CTX-M clusters. In silico analyses have shown that this event has occurred at least nine times; in CTX-M-1 cluster (3), CTX-M-2 and CTX-M-9 clusters (2 each), and CTX-M-8 and CTX-M-25 clusters (1 each). This has been mainly produced by the participation of genetic mobilization units… CONTINUE READING
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Epidemiology and evolution of β-lactamases,

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