CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China.

Abstract

The chimeric bla(CTX-M-123) gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla(CTX-M-123) is carried on related, but not identical, ~90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 blaCTX-M-55 gene on an additional IncI2 plasmid.

DOI: 10.1128/AAC.00541-13

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Cite this paper

@article{He2013CTXM123AN, title={CTX-M-123, a novel hybrid of the CTX-M-1 and CTX-M-9 Group β-lactamases recovered from Escherichia coli isolates in China.}, author={Dandan He and Sally R. Partridge and Jianzhong Shen and Zhen-ling Zeng and Lanping Liu and Lili Rao and Luchao Lv and Jian-Hua Liu}, journal={Antimicrobial agents and chemotherapy}, year={2013}, volume={57 8}, pages={4068-71} }