CTRP3/cartducin promotes proliferation and migration of endothelial cells


CTRP3/cartducin, a novel secretory protein, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. CTRP3/cartducin gene is transiently up-regulated in a balloon-injured rat carotid artery tissue. In this study, we report a new function of CTRP3/cartducin as a regulator of angiogenic processes. CTRP3/cartducin promoted proliferation and migration of mouse endothelial MSS31 cells in a dose-dependent manner. Further, stimulation of MSS31 by CTRP3/cartducin led to activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK). MAPK/ERK kinase 1/2 (MEK1/2) inhibitor, U0126, and p38 MAPK inhibitor, SB203580, blocked the CTRP3/cartducin-induced cell proliferation, and migration was blocked by U0126, but not the SB203580. Taken together, these results suggest that CTRP3/cartducin may be involved as a novel angiogenic factor in the formation of neointima following angioplasty.

DOI: 10.1007/s11010-007-9506-6

5 Figures and Tables

Citations per Year

375 Citations

Semantic Scholar estimates that this publication has 375 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Akiyama2007CTRP3cartducinPP, title={CTRP3/cartducin promotes proliferation and migration of endothelial cells}, author={Hironori Akiyama and Souhei Furukawa and Satoshi Wakisaka and Takashi Maeda}, journal={Molecular and Cellular Biochemistry}, year={2007}, volume={304}, pages={243-248} }