CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism.

@article{Peterson2013CTRP3AD,
  title={CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism.},
  author={Jonathan M Peterson and Marcus M Seldin and Zhikui Wei and Susan M. Aja and G. William Wong},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2013},
  volume={305 3},
  pages={G214-24}
}
CTRP3 is a secreted plasma protein of the C1q family that helps regulate hepatic gluconeogenesis and is downregulated in a diet-induced obese state. However, the role of CTRP3 in regulating lipid metabolism has not been established. Here, we used a transgenic mouse model to address the potential function of CTRP3 in ameliorating high-fat diet-induced metabolic stress. Both transgenic and wild-type mice fed a high-fat diet showed similar body weight gain, food intake, and energy expenditure… CONTINUE READING
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