CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft.

@article{Tomasoni2000CTLA4IgGT,
  title={CTLA4Ig gene transfer prolongs survival and induces donor-specific tolerance in a rat renal allograft.},
  author={Susanna Tomasoni and Nadia Azzollini and Federica Casiraghi and Maurizio Colognesi Capogrossi and Giuseppe Remuzzi and Ariela Benigni},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 4},
  pages={747-52}
}
Organ transplantation requires lifelong antirejection therapy, which carries the risk of infection and cancer. A revolutionary approach is to transduce the organ graft with immunomodulatory genes to render them tolerated with no need of systemic immunosuppression. Prolonged allograft survival was achieved by adenovirus-mediated transduction of the cold-preserved kidney with sequences encoding CTLA4Ig, a recombinant fusion protein that blocks T cell activation. Organ expression of the transgene… CONTINUE READING