CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus.

  title={CTLA4 polymorphism in Spanish patients with systemic lupus erythematosus.},
  author={Francisco Aguilar and Bel{\'e}n Torres and Julio S{\'a}nchez-Rom{\'a}n and Antonio N{\'u}{\~n}ez-Rold{\'a}n and Mar{\'i}a-Francisca Gonz{\'a}lez-Escribano},
  journal={Human immunology},
  volume={64 10},
The cytotoxic T-lymphocyte antigen 4 (CTLA4, CD152) gene is a positional and functional candidate gene to susceptibility to systemic lupus erythematosus (SLE) because CTLA4 gene maps in the described SLE risk region 2q33 and CTLA4 molecule has an inhibitory effect on T-cell activation. Several polymorphisms have been described in CTLA4 gene, among them, a T/C change at position -1722, a C/T transition at position -319, and another A/G transition at position +49. The aim of this study was to… CONTINUE READING

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