CTLA4 gene polymorphisms are associated with chronic bronchitis.

  title={CTLA4 gene polymorphisms are associated with chronic bronchitis.},
  author={Guohua Zhu and Alvar Agust{\'i} and Amund Gulsvik and Per S. Bakke and Harvey O Coxson and David A. Lomas and Edward K. Silverman and Sreekumar G Pillai},
  journal={The European respiratory journal},
  volume={34 3},
Chronic obstructive pulmonary disease (COPD) is characterised by chronic and progressive dyspnoea, cough and sputum production. T-lymphocytes may play a key role in the pathogenesis of COPD and chronic bronchitis. Cytotoxic T-lymphocyte antigen (CTLA) 4 is a potential candidate gene because it modulates T-cell activation. Genetic association between nine CTLA4 single nucleotide polymorphisms (SNPs) and chronic bronchitis was assessed in 606 pedigrees (1,896 individuals) from the International… CONTINUE READING
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  • SG Pillai, G Zhu, A Gulsvik
  • Am J Respir Crit Care Med
  • 2007

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