CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population.

@article{Ko2010CTLA4IgMD,
  title={CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population.},
  author={Hyeok-Jae Ko and Mi-La Cho and Seon-Yeong Lee and Hye Jwa Oh and Yu-Jung Heo and Young-Mee Moon and Chang-Min Kang and Seung-Ki Kwok and Ji Hyeon Ju and Sung-Hwan Park and Kyung-Su Park and Hang-Rae Kim},
  journal={Journal of autoimmunity},
  year={2010},
  volume={34 2},
  pages={111-20}
}
Cytotoxic T lymphocyte antigen-4 (CTLA4) and IgG fusion protein, CTLA4-Ig, is a therapeutic agent used for rheumatoid arthritis. It binds B7 molecules on dendritic cells (DCs) and thereby blocks B7/CD28 costimulatory interaction and inhibits effective T cell proliferation. However, the effect of CTLA4-Ig on the regulatory T cell (Treg) is still not known. In this study, we investigated the influence of CTLA4-Ig on the CD4+CD25+Foxp3+ Treg population in collagen-induced arthritis (CIA) mouse… CONTINUE READING
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