CTLA4+49 A/G and CT60 polymorphisms in Dutch coeliac disease patients

Abstract

Coeliac disease is an autoimmune disorder, characterised by villous atrophy of the small intestine, which results from a T-cell-mediated response to gluten-derived peptides. The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is involved in the regulation of T-cell activation and the CTLA4+49 A/G polymorphism in exon 1 has been implicated in several… (More)
DOI: 10.1038/sj.ejhg.5201165

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