CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.

@article{PrezGarca2007CTLA4PA,
  title={CTLA-4 polymorphisms and clinical outcome after allogeneic stem cell transplantation from HLA-identical sibling donors.},
  author={Arianne P{\'e}rez-Garc{\'i}a and Rafael de la C{\'a}mara and Jos{\'e} Rom{\'a}n-G{\'o}mez and Antonio Jim{\'e}nez-Velasco and Maite Encuentra and Jos{\'e} Bartolom{\'e} Nieto and Javier de la Rubia and {\'A}lvaro Urbano-Isp{\'i}zua and Salut Brunet and Arturo Iriondo and Marcos Gonzalez and David Serrano and Ildefonso Espigado and Carlos Armando L{\'o}pez Solano and Josep-Maria Ribera and Josep Mar{\'i}a Pujal and Montserrat Hoyos and David Gallardo},
  journal={Blood},
  year={2007},
  volume={110 1},
  pages={461-7}
}
CTLA-4 is an inhibitory molecule that down-regulates T-cell activation. Although polymorphisms at CTLA-4 have been correlated with autoimmune diseases their association with clinical outcome after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has yet to be explored. A total of 5 CTLA-4 single-nucleotide polymorphisms were genotyped on 536 HLA-identical sibling donors of allo-HSC transplants. Genotypes were tested for an association with patients' posttransplantation outcomes… CONTINUE READING

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