CTLA-4 in mesothelioma patients: tissue expression, body fluid levels and possible relevance as a prognostic factor

@article{Roncella2016CTLA4IM,
  title={CTLA-4 in mesothelioma patients: tissue expression, body fluid levels and possible relevance as a prognostic factor},
  author={Silvio Roncella and Stefania Laurent and Vincenzo Fontana and Paola Ferro and Maria Cristiana Franceschini and Sandra Salvi and Serena Varesano and Simona Boccardo and Antonella Vigani and A. E. Morabito and Pier Aldo Canessa and Ugo Giannoni and I. N. Rosenberg and Alessandro Valentino and Franco Fedeli and Domenico Franco Merlo and Marcello Ceppi and Salvatore Riggio and Massimo Romani and Daniele Saverino and Alessandro Poggi and Maria Pia Pistillo},
  journal={Cancer Immunology, Immunotherapy},
  year={2016},
  volume={65},
  pages={909-917}
}
CTLA-4 function as a negative regulator of T cell-mediated immune response is well established, whereas much less is known about the immunoregulatory role of its soluble isoform (sCTLA-4). No data are available on CTLA-4 expression and prognostic impact in malignant pleural mesothelioma (MPM). We investigated, by immunohistochemistry, CTLA-4 expression in tumor tissues and, by ELISA, sCTLA-4 levels in sera and matched pleural effusions from 45 MPM patients. Prognostic effect of CTLA-4… CONTINUE READING