CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.

Abstract

OBJECTIVE The aim of this study was to investigate whether four single nucleotide polymorphisms (SNPs) in CTLA-4 gene are associated with chronic obstructive pulmonary disease (COPD) in a Chinese population. METHODS Samples were collected from a Chinese population and analyzed for the association of SNPs in CTLA-4 gene with COPD in a case-control study. Four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were chosen and genotyped. The results were then analyzed using statistical methods. RESULTS We found that none of these four SNPs (rs231775, rs3087243, rs231725, rs5742909) in CTLA-4 gene were associated with the disease. CONCLUSION Our data suggested that there was no significant association between these four SNPs in CTLA-4 gene and COPD susceptibility in a Chinese population.

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Cite this paper

@article{Deng2013CTLA4GP, title={CTLA-4 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease.}, author={Lijing Deng and Haixia Zhou and Jing Yang and Jun Xiao and Bo Wang and Lan Wang and Xuemei Ou and Yulin Feng}, journal={International journal of clinical and experimental pathology}, year={2013}, volume={6 11}, pages={2548-53} }