CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.

@article{Auwera1997CTLA4GP,
  title={CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers. The Belgian Diabetes Registry.},
  author={Bart J R Van der Auwera and ChrisG. VandeWalle and Frans Schuit and Frederic Winnock and Ivo H De Leeuw and S Van Imschoot and Gerard Lamberigts and Frans K. Gorus},
  journal={Clinical and experimental immunology},
  year={1997},
  volume={110 1},
  pages={98-103}
}
Apart from genes in the HLA complex (IDDM1) and the variable number of tandem repeats in the 5' region of the insulin gene (INS VNTR, IDDM2), several other loci have been proposed to contribute to IDDM susceptibility. Recently, linkage and association have been shown between the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene on chromosome 2q and IDDM. In a registry-based group of 525 recent-onset IDDM patients <40 years old we investigated the possible interactions of a CTLA-4 gene A… CONTINUE READING
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