CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis.

@article{Laurent2007CTLA4EB,
  title={CTLA-4 expressed by chemoresistant, as well as untreated, myeloid leukaemia cells can be targeted with ligands to induce apoptosis.},
  author={Stefania Laurent and Giulio Lelio Palmisano and Alberto Maria Martelli and Tomohiro Kato and Pier Luigi Tazzari and Ivana Pierri and Marino Clavio and Beatrice Dozin and Giuseppe Balbi and Mauro Megna and A. E. Morabito and Teresa Lamparelli and Andrea Bacigalupo and Marco Gobbi and Maria Pia Pistillo},
  journal={British journal of haematology},
  year={2007},
  volume={136 4},
  pages={597-608}
}
We have previously reported that about 80% of acute myeloid leukaemia (AML) samples tested at diagnosis constitutively expressed cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4). The present study compared CTLA-4 expression and function of leukaemic cells from AML patients at diagnosis with those from AML patients resistant to conventional chemotherapy. We also explored the possibility of targeting CTLA-4 for apoptosis induction in chemoresistant AML cells. AML cells either from untreated… CONTINUE READING