CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.

@article{Jackman2007CTLA4DR,
  title={CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets.},
  author={Rachael P. Jackman and Fran Balamuth and Kim Bottomly},
  journal={Journal of immunology},
  year={2007},
  volume={178 9},
  pages={5543-51}
}
Primary murine Th1 and Th2 cells differ in the organization of the immunological synapse, with Th1 cells, but not Th2 cells, clustering signaling molecules at the T cell/B cell synapse site. We sought to determine whether differential costimulatory signals could account for the differences observed. We found that Th2 cells express higher levels of CTLA-4 than Th1 cells, and demonstrated that Th2 cells lacking CTLA-4 are now able to cluster the TCR with the same frequency as Th1 cells… CONTINUE READING