CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice

Abstract

Previous studies by others using transplantable murine tumor models have demonstrated that the administration of antibodies that block CTLA-4 interaction with B7 can provoke the elimination of established tumors, and that the tumor suppression is mediated by T-cells and/or cells expressing NK1.1. Studies from our lab have established in a human/severe… (More)
DOI: 10.1007/s00262-005-0668-3

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@article{Sabel2005CTLA4BA, title={CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice}, author={Michael S Sabel and Stephen Hess and Nejat K. Egilmez and Thomas F. Conway and Fang-An Chen and Richard B. Bankert}, journal={Cancer Immunology, Immunotherapy}, year={2005}, volume={54}, pages={944-952} }