CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis.

@article{Veen2003CTLA4AC,
  title={CTLA-4 and CD28 gene polymorphisms in susceptibility, clinical course and progression of multiple sclerosis.},
  author={Tineke van Veen and J. Bart A. Crusius and Lisa M L van Winsen and Bing Xia and Frederik Barkhof and A Salvador Pe{\~n}a and Chris H. Polman and Bernard M. J. Uitdehaag},
  journal={Journal of neuroimmunology},
  year={2003},
  volume={140 1-2},
  pages={188-93}
}
The balance between CD28 and CTLA-4 signalling is important for regulation of the immune response. We were interested whether a genetically mediated disturbance of this balance could be related to susceptibility or severity of multiple sclerosis (MS). We examined three polymorphisms in these genes, CTLA-4-318, CTLA-4+49 and CD28-I3+17, in 514 patients with MS and 181 controls. As the loci cannot be assumed independent of each other, we analysed the effects of each of the three polymorphisms… CONTINUE READING