CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.

@article{Kolar2009CTLA4C,
  title={CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.},
  author={Paula Kolar and Karin Knieke and Johannes K Hegel and Dagmar Quandt and Gerd ‐ R{\"u}diger Burmester and Holger Hoff and Monika C Brunner-Weinzierl},
  journal={Arthritis and rheumatism},
  year={2009},
  volume={60 1},
  pages={123-32}
}
OBJECTIVE CD4+CD25+ regulatory T cells (known as Treg cells) suppress unwanted and autoreactive T cell responses. Treg cells express the costimulatory molecule CTLA-4 intracellularly, but the mechanisms by which Treg cells exploit CTLA-4 signaling remain unclear. The present study was undertaken to investigate the role of CTLA-4 in controlling the homeostasis and suppressive function of Treg cells. METHODS Murine Treg cells were analyzed by flow cytometry for coexpression of CTLA-4 and… CONTINUE READING