CTLA-4 (+49A/G) Polymorphism and Type-1 Diabetes in Turkish Children

  title={CTLA-4 (+49A/G) Polymorphism and Type-1 Diabetes in Turkish Children},
  author={Fatih Çelmeli and Doğa T{\"u}rkkahraman and Deniz {\"O}zel and Sema Akçurin and Olcay Yeğin},
  booktitle={Journal of clinical research in pediatric endocrinology},
OBJECTIVE To evaluate the contribution of cytotoxic T-Iymphocyte antigen-4(CTLA-4)+49A/G polymorphism to the susceptibility to type-1 diabetes (T1D) in Turkish children. METHODS A case-control study was designed to include 91 Turkish children with T1D and 99 healthy controls. CTLA-4 (+99A/G) gene polymorphism typing was done by PCR amplification followed by restriction fragment length polymorphism method. RESULTS The genotype and allele frequencies of the CTLA-4 (+99A/G)polymorphism in… CONTINUE READING
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