CTLA-4 : A Negat ive Regulator

  title={CTLA-4 : A Negat ive Regulator},
  author={Nitin J. Karandikar and Carol L. Vanderlugt and Theresa L. Walunas and Stephen D Miller and Jeffrey A Bluestone},
CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to examine the role of CTLA-4 in regulating autoimmune disease. Murine relapsing-remitting experimental autoimmune encephalomyelitis (R-EAE) is a demyelinating disease mediated by PLP139-151-specific CD4… CONTINUE READING