CTLA-4 + 49 A / G and CT 60 gene polymorphisms in primary Sjögren syndrome

  title={CTLA-4 + 49 A / G and CT 60 gene polymorphisms in primary Sj{\"o}gren syndrome},
  author={Jacques-Eric Gottenberg and Pascale Loiseau and Mariam Azarian and Chun Chen and Nicolas Cagnard and Eric Hachulla and Xavier Pu{\'e}chal and Matthew Fittall and Dominique J. Charron and Xavier Mariette and Corinne Miceli-Richard},
CTLA-4 encodes cytotoxic T lymphocyte-associated antigen-4, a cell-surface molecule providing a negative signal for T-cell activation. CTLA-4 gene polymorphisms have been widely studied in connection with genetic susceptibility to various autoimmune diseases, but studies have led to contradictory results in different populations. This case-control study sought to investigate whether CTLA-4 CT60 and/or +49A/G polymorphisms were involved in the genetic predisposition to primary Sjögren syndrome… CONTINUE READING

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