CTL control of EBV in nasopharyngeal carcinoma (NPC): EBV-specific CTL responses in the blood and tumors of NPC patients and the antigen-processing function of the tumor cells.

@article{Lee2000CTLCO,
  title={CTL control of EBV in nasopharyngeal carcinoma (NPC): EBV-specific CTL responses in the blood and tumors of NPC patients and the antigen-processing function of the tumor cells.},
  author={Steven P. Lee and Antoni T. Chan and Sing Tak Gloria Cheung and Wendy A. Thomas and Debbie CroomCarter and Christopher Dawson and Chung Hung Tsai and Sing-fai Leung and Philip James Johnson and Doll P. Huang},
  journal={Journal of immunology},
  year={2000},
  volume={165 1},
  pages={573-82}
}
Undifferentiated nasopharyngeal carcinoma (NPC) is latently infected with EBV and expresses a restricted number of viral proteins. Studies in healthy virus carriers have demonstrated that at least some of these proteins can act as targets for HLA class I-restricted CTLs. Therefore we have explored the possibility of a CTL-based therapy for NPC by characterizing EBV-specific CTL responses in 10 newly diagnosed NPC cases and 21 healthy virus carriers from Southeast Asia. Using the autologous EBV… CONTINUE READING