CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.

  title={CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC.},
  author={Youjun Chen and Ingrid E Blom and S. A. Mendes de S{\'a} and Roel Goldschmeding and David J. Abraham and Andrew Leask},
  journal={Kidney international},
  volume={62 4},
BACKGROUND The induction of excess matrix in renal fibrosis seems to be mediated, at least in part, by the transforming growth factor-beta (TGF-beta)-mediated induction of connective tissue growth factor (CTGF) in mesangial cells. METHODS By examining CTGF protein and mRNA expression and promoter activity in the presence or absence of TGF-beta or inhibitors, the signaling pathways controlling basal and TGF-beta-induced CTGF expression in mesangial cells were investigated. RESULTS TGF-beta… CONTINUE READING
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