CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.

@article{Tan2009CTGFEM,
  title={CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells.},
  author={Tzu-Wei Tan and Chih-Ho Lai and Chun-Yiu Huang and Wei-Hung Yang and Hsien-Te Chen and Horng-chaung Hsu and Yi-chin Fong and Chih-Hsin Tang},
  journal={Journal of cellular biochemistry},
  year={2009},
  volume={107 2},
  pages={345-56}
}
Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Connective tissue growth factor (CTGF), a secreted protein that binds to integrins, modulates the invasive behavior of certain human cancer cells. However, the effect of CTGF on migration activity in human chondrosarcoma cells is mostly unknown. Here we found that CTGF increased the migration and expression of matrix metalloproteinase (MMP)-13 in human chondrosarcoma cells (JJ012… CONTINUE READING

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