CTF determination and correction for low dose tomographic tilt series.

@article{Xiong2009CTFDA,
  title={CTF determination and correction for low dose tomographic tilt series.},
  author={Quanren Xiong and Mary Morphew and Cindi L. Schwartz and Andreas Hoenger and David N. Mastronarde},
  journal={Journal of structural biology},
  year={2009},
  volume={168 3},
  pages={
          378-87
        }
}
The resolution of cryo-electron tomography can be limited by the first zero of the microscope's contrast transfer function (CTF). To achieve higher resolution, it is critical to determine the CTF and correct its phase inversions. However, the extremely low signal-to-noise ratio (SNR) and the defocus gradient in the projections of tilted specimens make this process challenging. Two programs, CTFPLOTTER and CTFPHASEFLIP, have been developed to address these issues. CTFPLOTTER obtains a 1D power… CONTINUE READING
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