CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.

@article{Hong2013CTENPS,
  title={CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation.},
  author={Shiao-Ya Hong and Yi-Ping Shih and Tianhong Li and Kermit L. Carraway and Su Hao Lo},
  journal={Cancer research},
  year={2013},
  volume={73 16},
  pages={5266-76}
}
Activation of EGF receptor (EGFR) triggers signaling pathways regulating various cellular events that contribute to tissue development and function. Aberrant activation of EGFR contributes to tumor progression as well as therapeutic resistance in patients with cancer. C-terminal tensin-like (CTEN; TNS4) is a focal adhesion molecule that is a member of the tensin family. Its expression is upregulated by EGF and elevated CTEN mediates EGF-induced cell migration. In the presence of CTEN, we found… CONTINUE READING