CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons.

Abstract

The CCCTC-binding factor (CTCF) is a key molecule for chromatin conformational changes that promote cellular diversity, but nothing is known about its role in neurons. Here, we produced mice with a conditional knockout (cKO) of CTCF in postmitotic projection neurons, mostly in the dorsal telencephalon. The CTCF-cKO mice exhibited postnatal growth… (More)
DOI: 10.1016/j.celrep.2012.06.014

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