CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

Abstract

Epigenetic alterations, particularly in DNA methylation, are ubiquitous in cancer, yet the molecular origins and the consequences of these alterations are poorly understood. CTCF, a DNA-binding protein that regulates higher-order chromatin organization, is frequently altered by hemizygous deletion or mutation in human cancer. To date, a causal role for CTCF… (More)
DOI: 10.1016/j.celrep.2014.04.004

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