CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression

@article{Zhao2016CTCFCW,
  title={CTCF cooperates with noncoding RNA MYCNOS to promote neuroblastoma progression through facilitating MYCN expression},
  author={Xudong Zhao and Da-ming Li and Jiarui Pu and Hai-bo Mei and Dan Yang and Xuan Xiang and Hong-ping Qu and K Huang and Lemin Zheng and Qiangsong Tong},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={3565-3576}
}
Previous studies have indicated the important roles of MYCN in tumorigenesis and progression of neuroblastoma (NB), the most common extracranial solid tumor derived from neural crest in childhood. However, the regulatory mechanisms of MYCN expression in NB still remain largely unknown. In this study, through mining public microarray databases and analyzing the cis-regulatory elements and chromatin immunoprecipitation data sets, we identified CCCTC-binding factor (CTCF) as a crucial… CONTINUE READING

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