CTCF Elements Direct Allele-Specific Undermethylation at the Imprinted H19 Locus


The H19 imprinted gene locus is regulated by an upstream 2 kb imprinting control region (ICR) that influences allele-specific expression, DNA methylation, and replication timing. This ICR becomes de novo methylated during late spermatogenesis in the male but emerges from oogenesis in an unmethylated form, and this allele-specific pattern is then maintained… (More)
DOI: 10.1016/j.cub.2004.05.041


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