CTCF Binding Polarity Determines Chromatin Looping.

  title={CTCF Binding Polarity Determines Chromatin Looping.},
  author={Elzo de Wit and Erica S M Vos and Sjoerd Johannes Bastiaan Holwerda and Christian Valdes-Quezada and Marjon J. A. M. Verstegen and H Eric Teunissen and Erik Splinter and Patrick J E C Wijchers and Peter H. L. Krijger and Wouter de Laat},
  journal={Molecular cell},
  volume={60 4},
CCCTC-binding factor (CTCF) is an architectural protein involved in the three-dimensional (3D) organization of chromatin. In this study, we assayed the 3D genomic contact profiles of a large number of CTCF binding sites with high-resolution 4C-seq. As recently reported, our data also suggest that chromatin loops preferentially form between CTCF binding sites oriented in a convergent manner. To directly test this, we used CRISPR/Cas9 genome editing to delete core CTCF binding sites in three loci… CONTINUE READING
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