CTCF, cohesin, and histone variants: connecting the genome.

  title={CTCF, cohesin, and histone variants: connecting the genome.},
  author={Jean-François Millau and Luc Gaudreau},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={89 5},
During the last decades our view of the genome organization has changed. We moved from a linear view to a looped view of the genome. It is now well established that inter- and intra-connections occur between chromosomes and play a major role in gene regulations. These interconnections are mainly orchestrated by the CTCF protein, which is also known as the "master weaver" of the genome. Recent advances in sequencing and genome-wide studies revealed that CTCF binds to DNA at thousands of sites… CONTINUE READING

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