CTBP1/CYP19A1/estradiol axis together with adipose tissue impacts over prostate cancer growth associated to metabolic syndrome.

@article{Massillo2019CTBP1CYP19A1estradiolAT,
  title={CTBP1/CYP19A1/estradiol axis together with adipose tissue impacts over prostate cancer growth associated to metabolic syndrome.},
  author={Cintia Massillo and Guillermo Nicol{\'a}s Dalton and Juliana Porretti and Georgina Daniela Scalise and Paula Luc{\'i}a Farr{\'e} and Flavia Piccioni and Florencia Secchiari and Natalia Pascuali and Colin Clyne and Kevin H Gardner and Paola De Luca and Adriana De Siervi},
  journal={International journal of cancer},
  year={2019},
  volume={144 5},
  pages={
          1115-1127
        }
}
  • Cintia Massillo, Guillermo Nicolás Dalton, +9 authors Adriana De Siervi
  • Published in
    International journal of…
    2019
  • Medicine
  • Metabolic syndrome (MeS) increases prostate cancer (PCa) risk and aggressiveness. C-terminal binding protein 1 (CTBP1) is a transcriptional co-repressor of tumor suppressor genes that is activated by low NAD+ /NADH ratio. Previously, our group established a MeS and PCa mice model that identified CTBP1 as a novel link associating both diseases. We found that CTBP1 controls the transcription of aromatase (CYP19A1), a key enzyme that converts androgens to estrogens. The aim of this work was to… CONTINUE READING

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