CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen.

@article{Mowat2001CTA1DDimmuneSC,
  title={CTA1-DD-immune stimulating complexes: a novel, rationally designed combined mucosal vaccine adjuvant effective with nanogram doses of antigen.},
  author={Allan McI Mowat and Anne M. Donachie and Sara J{\"a}gewall and Karin Sch{\"o}n and Bj{\"o}rn L{\"o}wenadler and Kristian Dalsgaard and Peter Kaastrup and Nils Y Lycke},
  journal={Journal of immunology},
  year={2001},
  volume={167 6},
  pages={3398-405}
}
Mucosally active vaccine adjuvants that will prime a full range of local and systemic immune responses against defined antigenic epitopes are much needed. Cholera toxin and lipophilic immune stimulating complexes (ISCOMS) containing Quil A can both act as adjuvants for orally administered Ags, possibly by targeting different APCs. Recently, we have been successful in separating the adjuvant and toxic effects of cholera toxin by constructing a gene fusion protein, CTA1-DD, that combines the… CONTINUE READING

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