CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.

S. Lee; Woo-Dong Nam; Hee-Jun Na; Young-Lai Cho; K. Ha; Jong-Yun Hwang; H. Lee; S. Kim; Y. Kwon; Y. Kim

DOI:10.1016/j.bcp.2008.04.006

Corpus ID: 41203589

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.

@article{Lee2008CT20126AN,
  title={CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.},
  author={S. Lee and Woo-Dong Nam and Hee-Jun Na and Young-Lai Cho and K. Ha and Jong-Yun Hwang and H. Lee and S. Kim and Y. Kwon and Y. Kim},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 1},
  pages={
          79-90
        }
}

S. Lee, Woo-Dong Nam, +7 authors Y. Kim

Published 2008

Medicine

Biochemical pharmacology

The colchicine-derived CT20126 compound has recently been shown to exert an immune regulatory effect and prolong the survival of allograft skins. In this study, we explored the anti-inflammatory and anti-arthritic effects of CT20126 in vivo and in vitro as well as investigated its underlying action mechanism. CT20126 suppressed the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, tumor necrosis factor-alpha, and interleukin-1beta as well as the production of nitric oxide… CONTINUE READING

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