CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.

@article{Doronkin2002CSN5Jab1MA,
  title={CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.},
  author={Sergey Doronkin and Inna Djagaeva and Steven K. Beckendorf},
  journal={Development},
  year={2002},
  volume={129 21},
  pages={5053-64}
}
The COP9 signalosome (CSN) is linked to signaling pathways and ubiquitin-dependent protein degradation in yeast, plant and mammalian cells, but its roles in Drosophila development are just beginning to be understood. We show that during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte. The EGFR ligand Gurken is essential for both axes, and our results show that CSN5 mutations block the… CONTINUE READING
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The COP 9 signalosome inhibits p 27 ( kip 1 ) degradation and impedes G 1S phase progression via deneddylation of SCF Cul 1

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