CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability

@article{Wee2005CSNFC,
  title={CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability},
  author={Susan Wee and Rory K. Geyer and Takashi Toda and Dieter A. Wolf},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={387-391}
}
The COP9 signalosome (CSN) is known to bind cullin-RING ubiquitin ligases (CRLs) and to promote their activity in vivo. The mechanism of this stimulation has remained enigmatic because CSN's intrinsic and associated enzymatic activities paradoxically inhibit CRL activity in vitro. Reconciling this paradox, we show here that Csn5-catalysed cullin (Cul) deneddylation and Ubp12-mediated deubiquitination cooperate in maintaining the stability of labile substrate adapters, thus facilitating CRL… CONTINUE READING
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