CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

@article{Arias2002CSLindependentNS,
  title={CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?},
  author={Alfonso Martinez Arias and Vincent Zecchini and Keith Brennan},
  journal={Current opinion in genetics & development},
  year={2002},
  volume={12 5},
  pages={
          524-33
        }
}
During development, signalling by members of the Notch family of cell surface receptors plays a widespread role in the assignation of cell fates within the process of lateral inhibition. This function of Notch is mediated by a well-established mechanism that relies on a ligand-induced release of the intracellular domain of Notch (NICD) and the interaction of this fragment with members of the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. However… CONTINUE READING

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