CSH guidelines for the diagnosis and treatment of drug-induced liver injury

@article{Yu2017CSHGF,
  title={CSH guidelines for the diagnosis and treatment of drug-induced liver injury},
  author={Yue-Cheng Yu and Yi-Min Mao and Cheng-wei Chen and Jinjun Chen and Jun Chen and Wen-Ming Cong and Yang Ding and Zhong-Ping Duan and Qing-chun Fu and Xiaolei Guo and Peng Hu and Xi-qi Hu and Ji Dong Jia and Rongtao Lai and Dong-liang Li and Ying-Xia Liu and Lungen Lu and Shiwu Ma and Xiong Ma and Yue-min Nan and Hong Ren and Tao Shen and Hao Wang and Ji-yao Wang and Tai-ling Wang and Xiao‐jin Wang and Lai Wei and Qing Xie and Wen Xie and Chang-qing Yang and Dong-Liang Yang and Yanying Yu and Min-de Zeng and Li Zhang and Xin-Yan Zhao and Hui Zhuang},
  journal={Hepatology International},
  year={2017},
  volume={11},
  pages={221 - 241}
}
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical molecules, biological agents, traditional Chinese medicines (TCM), natural medicines (NM), health products (HP), and dietary supplements (DS). Idiosyncratic DILI is far more common than intrinsic DILI clinically and can be classified into hepatocellular injury, cholestatic injury, hepatocellular-cholestatic mixed injury, and vascular injury… 
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TLDR
The history and current status of corticosteroid use in liver diseases and the pros and cons of cortICosteroid treatment in DILI are summarized, the DILi candidates who may benefit from corticosterone therapy, the administration route and dosage, and the adverse effects related to corticOSToid use are explored.
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References

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ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
TLDR
This ACG Clinical Guideline is presented an evidence-based approach to diagnosis and management of DILI with special emphasis on DILi due to herbal and dietary supplements and DilI occurring in individuals with underlying liver disease.
Drug-induced liver injury: Icelandic lessons.
TLDR
The authors took advantage of the limited but well characterized population of Iceland and the excellent and centralized medical care system enjoyed by that population to estimate the incidence of drug-induced liver injury as 19 cases per 100,000 persons per year, somewhat higher than previous estimates.
Role of immune reactions in drug-induced liver injury (DILI)
TLDR
A variety of hypotheses for the pathogenesis of DILI center around a pathogenic role of drug- (or drug-metabolite–) specific adaptive immune cells, as well as hepatic-injury–induced innate immune responses in the development, progression, and/or resolution of D ILI.
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TLDR
There are no objective tests to definitively diagnose DILI and the diagnosis depends on thorough and accurate history taking, follow-up of the patient's clinical course and excluding more common causes of liver injury.
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The diagnosis of drug-induced liver injury (DILI) is a challenging problem, often confounded by incomplete clinical information and the difficulty of eliciting exposure to herbal products,
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TLDR
The new and updated DILI registries for 2010 are presented, including the latest information on the causes and outcomes of non-acetaminophen DILi cases in the US Acute Liver Failure Study Group database.
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TLDR
An update on the epidemiology, pathogenic mechanisms, diagnosis, outcome, risk factors for idiosyncratic drug-induced hepatotoxicity, specific classes of drug hepatot toxicity and biomarkers to predict DILI are covered.
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TLDR
Drug induced liver injury is an uncommon cause of acute and chronic liver injury of increasing importance to patients, clinicians, and regulators and recent studies have shown that statins are actually safe and efficacious to use in hyperlipidemic patients with chronic liver disease.
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